Interleukin-33 modulates inflammation in endometriosis
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چکیده
منابع مشابه
Interleukin-5 modulates interleukin-8 secretion in eosinophilic inflammation.
Serum and BALF (bronchoalveolar lavage fluid) IL-8 levels and serum levels were investigated in Toxocara canis infected guinea-pigs and the role of IL-5 as a modulator of cytokine secretion was studied. Serum levels increased early in infected animals, exceeding control levels 4 h after infection, peaked between days 6 and 18, and continued to exceed control levels after 48 days of infection. S...
متن کاملSerum and peritoneal interleukin-33 levels are elevated in deeply infiltrating endometriosis.
BACKGROUND Interleukin 33 (IL-33) is a cytokine involved in fibrotic disorders. We have analyzed IL-33 levels in the sera and peritoneal fluids of women with various forms of endometriosis and investigated the correlation with disease activity. METHODS We conducted a prospective laboratory study in a tertiary-care university hospital between January 2005 and December 2010. Five hundred and te...
متن کاملInterleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice.
RATIONALE Chronic low-grade inflammation involving adipose tissue likely contributes to the metabolic consequences of obesity. The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in adipose tissue, but their role in adipose tissue inflammation during obesity is unclear. OBJECTIVE To examine the functional role of IL-33 in adipose tissues and investigate the effects on adipose ...
متن کاملInflammation and endometriosis.
Endometriosis is defined by presence of endometrial glands and stroma outside the uterine cavity and it affects approximately 5%-10% of women of reproductive age. Although endometriosis is usually considered to be due to retrograde menstruation, the true pathogenesis of this disease remains poorly understood. Endometriosis is associated with an inflammatory response and this inflammation leads ...
متن کاملAlternative splicing of interleukin-33 and type 2 inflammation in asthma.
Type 2 inflammation occurs in a large subgroup of asthmatics, and novel cytokine-directed therapies are being developed to treat this population. In mouse models, interleukin-33 (IL-33) activates lung resident innate lymphoid type 2 cells (ILC2s) to initiate airway type 2 inflammation. In human asthma, which is chronic and difficult to model, the role of IL-33 and the target cells responsible f...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-18224-x